Fig. 6. Roxyl-ZR suppresses UM1-luc orthotopic xenograft tumor growth and invasion. (A) Tumor growth was monitored by BLI every 7 days. Tumors treated with Roxyl-ZR were significantly inhibited compared with the other groups. (B) Growth curves of orthotopic tumors treated with Roxyl-ZR, vorinostat, abemaciclib, or vehicle. The regions of -interest of tumors as shown in (A) were measured. (C) Average body weights of xenograft tumor mice after treatment with Roxyl-ZR, vorinostat, abemaciclib, or vehicle. (D and E) Photographs of orthotopic tumors from the different groups. Roxyl-ZR prevented orthotopic tumors from invading into the adjacent muscle layers, as determined by HE staining.